Thesis

71 Incidence Peaks and the Role of Influenza Table 1: Population characteristics Parameter Outcome NT1 (N=981) NT2 (N=189) IH (N=356) P-value Sex Female 474 (48.4) 92 (49.2) 258 (72.7) <0.001 Male 505 (51.6) 95 (50.8) 97 (27.3) Age Years 20.28 (12.14) 21.2 (10.5) 22.51 (11.49) 0.005 Age group # Children 563 (57.4) 109 (57.7) 171 (48.0) 0.024 Adults 386 (39.3) 80 (42.3) 169 (47.5) Cataplexy presence Yes 932 (95.3) 0 (0) 0 (0) <0.001 No 46 (4.7) 180 (100) 277 (100) Age at onset cataplexy (years) 21.78 (12.48) - - - MSLT sleep latency (minutes) 3.88 (3.53) 5.57 (2.41) 7.58 (3.10) <0.001 Hypocretin-1 levels (pg/mL) <40 398 (74.1) 0 (0.0) 0 (0.0) <0.001 40-110 110 (20.5) 0 (0.0) 0 (0.0) 110-200 21 (3.9) 10 (10.1)† 4 (4.3)† >200 8 (1.5) 89 (89.9) 88 (95.7) HLA-DQB1*06:02 positivity Yes 839 (97.1) 58 (35.2) 35 (18.6) <0.001 No 25 (2.9) 107 (64.8) 153 (81.4) ESS Score 17.00 [14.00, 20.00] 15.0 [12.0, 17.5] 15.0 [12.0, 18.0] <0.001 The values represent means and standard deviations in round brackets for continuous variables and percentages for categorical variables. ESS scores are presented as medians and interquartile ranges in square brackets. # 32 NT1 and 16 IH patients had missing data in their age of symptom onset. † the 14 individuals with NT2 or IH and hypocretin-1 levels between 110-200 all had hypocretin-1 levels above 150. ESS = Epworth sleepiness scale; HLA = human leukocyte antigen; IH = idiopathic hypersomnia; MSLT = multiple sleep latency test; NT1 = narcolepsy type 1; NT2 = narcolepsy type 2; PSG = polysomnography. 3

RkJQdWJsaXNoZXIy MjY0ODMw