Table of contents Chapter 1 General Introduction 9 Section A – The Past: Identifying Potential Immunological Triggers for Central Disorders of Hypersomnolence Chapter 2 New 2013 Incidence Peak in Childhood Narcolepsy: More Than Vaccination? Sleep. 2021;44(2):zsaa172. 43 Chapter 3 2010 and 2013 Incidence Peaks in Narcolepsy and Idiopathic Hypersomnia Linked to Type A H1N1 and Type B Victoria Influenza Strains Submitted to: Proceedings of the National Academy of Sciences. 63 Chapter 4 Potential Immunological Triggers for Narcolepsy and Idiopathic Hypersomnia: Real-World Insights on Infections and Influenza Vaccinations Sleep Medicine. 2024;116:105–14. 91 Section B – The Present: Brain Structure and Functioning in Narcolepsy Type 1 Chapter 5 Widespread White Matter Connectivity Abnormalities in Narcolepsy Type 1: A Diffusion Tensor Imaging Study Neuroimage Clinical. 2019;24:101963. 131 Chapter 6 Widespread White Matter Axonal Loss in Narcolepsy Type 1 Submitted to: Sleep. 159 Chapter 7 The Sustained Attention to Response Task Shows Lower Cingulo-Opercular and Frontoparietal Activity in People with Narcolepsy Type 1: An fMRI Study on the Neural Regulation of Attention Brain Sciences. 2020;10(7):419. 195
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