54 Chapter 2 CI: [1.80, 6.39]), France (2.47-fold, 95% CI: [1.54, 6.15]), and Switzerland (2.84-fold, 95% CI: [1.54, 17.89]). Only in Czech Republic we found a significant increase (2.92-fold, 95% CI: [1.48, 142.80]) in adult NT1 in 2012. But the result should be interpreted cautiously considering the relative small number (n = 3) of adult patients. Thus the increase in 2013 was age-specific. Figure 5. The predictions of LOESS models for children/adolescent and adult cases in each country. The predicted values and their 95% predictive CIs are marked as green circles/lines, and the actual values are in black. The ratios and its 95% predictive CIs between the actual values and the predicted values are written in the figure, in black for the ratios in 2009–2011 seasons and in red for the ones in 2012–2013 season. Age-specific increase in 2013 was confirmed by analysing the children/ adult ratios that was not biased by the delayed diagnosis The changes of the ratios (i.e. children/adults) confirmed that the increase in 2013 was specific for childhood narcolepsy (Figure 6). The highest value was
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