52 Chapter 2 patients with an onset of EDS in 2009–2010 was diagnosed in 2009–2012 and this proportion was 70.7% (46 out of 65) in adult patients (see Figure 3, which showed the years of diagnosis of those patients who started EDS in 2009– 2010). These results also confirmed that some patients (35.7%, 51/143) were diagnosed several years later after the 2009–2010 pH1N1, which is more evident in children/adolescents than in adults (Figure 3). Figure 3. The year of diagnosis of children and adult patients starting EDS in 2009–2011. Both in children/adolescents and in adults we found significant overall increases in the number of actual cases with EDS onset in 2010 (Figure 4) compared with the predicted numbers (2.75-fold, 95% CI: [1.95, 4.69] and 2.43–fold, 95% CI: [2.05, 2.97], respectively). It was remarkable to notice that specifically in children we could also find a 2.09-fold (95% CI: [1.52, 3.32]) increase in 2013, which was not shown in adults.
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