38 Chapter 1 Table 2. Continued. Study Neuroimaging technique Disorder Sample size (number of females) Mean age, years (SD) Diagnosis * Medicated: unmedicated Main findings in patients (compared to controls) Patients Controls Patients Controls Witt et al. 2018 Task-based fMRI (working memory) NT1 17 (11) 20 (12) 16.5 (1.9) 17.4 (2.6) PSG, MSLT, cataplexy, CSF 15:2 Greater deactivation in NT1 in the default mode network during task performance. Deactivation of the anterior aspect of the default mode network correlated more with increased concentrations of Glutamate and decreased concentrations of GABA. Van Holst et al. 2018 Taskbased fMRI (inhibition) NT1 + IH NT1: 23 (11) IH: 15 (8) 20 (10) NT1: 36.8 (12.2) IH: 36.2 (12.9) 3.8 (8.4) PSG, MSLT, cataplexy, CSF 0:23** Greater activation and connectivity in NT1 within the ventral medial prefrontal cortex and motor cortex during a foodrelated task, but lower activation in the dorsal medial prefrontal cortex during a classic workingmemory task. Gool et al. 2020 Taskbased fMRI (vigilance) NT1 12 (4) 11 (4) 33.3 (10.5) 31.8 (13.4) PSG, MSLT, cataplexy, HLA, CSF 5**:7 Lower activation in NT1 in the cingulo-opercular, frontoparietal, arousal, motor, and visual networks when high vigilance demand task blocks progressed. Lower error-related activity in the left pre- and postcentral gyrus in NT1.
RkJQdWJsaXNoZXIy MjY0ODMw