37 Introduction Table 2. Continued. Study Neuroimaging technique Disorder Sample size (number of females) Mean age, years (SD) Diagnosis * Medicated: unmedicated Main findings in patients (compared to controls) Patients Controls Patients Controls Vaudano et al. 2019 Task-based fMRI (humour) NT1 21 (8) 21 (9) 11.3 (2.5) 12.7 (2.2) PSG, MSLT, cataplexy, HLA, CSF 0:21 Greater activation in NT1 in motor cortex, right thalamus, and left subthalamic nucleus during laughter. This activation was positively correlated with the absence of cataplexy. Juvodden et al. 2019 Task-based fMRI (humour) NT1 41 (31) 44 (24) 23.6 (11.4) 19.6 (8.4) PSG, MSLT, cataplexy, HLA, CSF 0:41** Greater activation in NT1 in the thalamus, pallidum, putamen, amygdala, brainstem, cerebellum, hippocampus, middle temporal gyrus, left precuneus, supramarginal gyrus and caudate. Ponz et al. 2010 Task-based fMRI (reward) NT1 9 (5) 9 (5) 33.8 (7.9) 34.7 (7.7) PSG, MSLT, cataplexy, HLA, CSF 0:9** Lower activation in NT1 in the ventral midbrain during high reward expectancy and during winning trials. Greater activation in accumbens and the ventral-medial prefrontal cortex correlated with NT1 disease duration. 1
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