35 Introduction Table 2. Continued. Study Neuroimaging technique Disorder Sample size (number of females) Mean age, years (SD) Diagnosis * Medicated: unmedicated Main findings in patients (compared to controls) Patients Controls Patients Controls Ballotta et al. 2021 fMRI (resting state) NT1 15 (6) 15 (6) 11.7 (3.0) 12.4 (2.8) PSG, MSLT, cataplexy, HLA, CSF 0:15 Lower functional connectivity in paediatric NT1 between lateral hypothalamus and left superior parietal lobule, hippocampus and parahippocampal gyrus, and between amygdala and post-central gyrus and several occipital regions. Increased connectivity between amygdala and inferior frontal gyrus, claustrum, insula, and putamen. Wu et al. 2022 fMRI (resting state) NT1 18 (8) 18 (7) 21.4 (5.4) 22.3 (4.6) PSG, MSLT, cataplexy, HLA, CSF 0:18 Greater low-frequency activity in NT1 in the bilateral fusiform gyrus, right precentral gyrus and left postcentral gyrus, and reduced low-frequency activity in the bilateral temporal pole and paracingulate gyri, left caudate nucleus, parahippocampus and precuneus and right amygdala and anterior cingulate. Findings correlated with MSLT SOREMPs and severity of depressive symptoms. 1
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