31 Introduction Table 2. Continued. Study Neuroimaging technique Disorder Sample size (number of females) Mean age, years (SD) Diagnosis * Medicated: unmedicated Main findings in patients (compared to controls) Patients Controls Patients Controls Dauvilliers et al. 2017 FDG-PET NT1 + IH NT1: 16 (4) IH: 9 (7) 19 (3) NT1: 30 (NR) IH: 27 (NR) 36 (NR) PSG, MSLT, cataplexy, CSF NT1: 0:16 IH: 0:9 Hypermetabolism in both patient groups in the anterior and middle cingulate, and insular cortex. No differences between NT1 and IH. Huang et al. 2016 FDG-PET NT1 71 (30) 20 (8) 16.2 (4.2) 15.1 (5.3) PSG, MSLT, cataplexy, HLA, CSF 0:71 Hypometabolism in NT1 in superior frontal, medial frontal, orbitofrontal, posterior cingulate and angular gyrus. Hypermetabolism in NT1 in the olfactory, hippocampus, parahippocampus, amygdala, fusiform, left inferior parietal lobe, left superior temporal lobe, basal ganglia, thalamus, cerebellum, right hypothalamus, midbrain and pons. Huang et al. 2018 FDG-PET NT1 + NT2 NT1:104 (37) NT2: 29 (10) 26 (10) NT1: 20.1 (9.1) NT2: 19.3 (5.6) 19.1 (5.3) PSG, MSLT, cataplexy, HLA 0:133 Hypermetabolism in NT1 compared to NT2 in the fusiform gyrus, striatum, hippocampus, thalamus, basal ganglia, and cerebellum. More hypometabolism in NT1 compared to NT2 in frontal lobe, posterior cingulate cortex, angular gyrus and parietal lobe and less hypometabolism in Heschl’s gyrus and paracentral lobule. 1
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