Thesis

322 Chapter 10 Appendix A PICO The following PICO was composed for the systematic literature search: Patient group: people with narcolepsy type 1 Intervention: opioid medication Control group: placebo or periods of no opioid medication Outcome: narcolepsy symptom severity (excessive daytime sleepiness, cataplexy, disturbed nocturnal sleep, hypnagogic hallucinations, sleep paralysis or daytime functioning) Search strategy PubMed/MEDLINE (conducted 1 January 2022): (“Disorders of Excessive Somnolence”[MeSH] OR “narcolepsy”[TW] OR “narcoleptic”[TW] OR “hypersomnia”[TW] OR “hypersomnolence”[TW] OR “cataplexy”[TW] OR “excessive daytime sleepiness”[TW]) AND (“Analgesics, Opioid”[MeSH] OR “Opiate Alkaloids”[MeSH] OR “Tramadol”[MeSH] OR “Morphine”[TW] OR “Codeine”[TW] OR “Fentanyl”[TW] OR “Oxycodone”[TW] OR “Naloxone”[TW] OR “Tramadol”[TW] OR “Alfentanil”[TW] OR “Buprenophine”[TW] OR “Hydromorphone”[TW] OR “Methadone”[TW] OR “Nalbuphine”[TW] OR “Nicomorphine”[TW] OR “Pentazocine”[TW] OR “Pethidine”[TW] OR “Piritramide”[TW] OR “Remifentanil”[TW] OR “Sufentanil”[TW] OR “Tapentadol”[TW] OR “Opioid”[TW] OR “Opioids”[TW]) Embase (conducted 1 January 2022): (‘Disorders of Excessive Somnolence’:ti,ab,kw OR narcolepsy:ti,ab,kw OR narcoleptic:ti,ab,kw OR hypersomnia:ti,ab,kw OR hypersomnolence:ti,ab,kw OR cataplexy:ti,ab,kw OR ‘excessive daytime sleepiness’:ti,ab,kw) AND (‘Analgesics Opioid’:ti,ab,kw OR ‘Opiate Alkaloids’:ti,ab,kw OR Tramadol:ti,ab,kw OR Morphine:ti,ab,kw OR Codeine:ti,ab,kw OR Fentanyl:ti,ab,kw OR Oxycodone:ti,ab,kw OR Naloxone:ti,ab,kw OR Tramadol:ti,ab,kw OR Alfentanil:ti,ab,kw OR Buprenophine:ti,ab,kw OR Hydromorphone:ti,ab,kw OR Methadone:ti,ab,kw OR Nalbuphine:ti,ab,kw OR Nicomorphine:ti,ab,kw OR Pentazocine:ti,ab,kw OR Pethidine:ti,ab,kw OR Piritramide:ti,ab,kw OR Remifentanil:ti,ab,kw OR Sufentanil:ti,ab,kw OR Tapentadol:ti,ab,kw OR Opioid:ti,ab,kw OR Opioids:ti,ab,kw)

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