315 Therapeutic Potential of Opioids in Narcolepsy Type 1 Table 3: Continued. Opioid Frequency Duration of use Method of administration and dosage (Medical) indication Effects of opioid Concurrent narcolepsy medication Remarks Tramadol 6 Multiple years within past 30 years ~ Tablet, 37.5-50 mg 0-3/day Generalised pain (back, hip, knee, head) Yes (modafinil) Self-reported impression that symptoms got better through less pain. 90 days † Tablet, 50 mg 2/ day Back pain Yes (modafinil) More difficult to sleep in and through the night. 10 weeks Capsule, 50 mg 2-3/day Shoulder pain Yes (modafinil, sodium oxybate) Slept more because of inactivity. 8 weeks Tablet, 50 mg 3/ day Lumbar hernia No Narcolepsy symptoms worsened (onset of cataplexy) just after stopping tramadol. No NT1 diagnosis at time of use. 2 weeks* Tablet, 37.5 mg 3/day Lumbar hernia Yes (modafinil, pitolisant, fluoxetine, sodium oxybate) 7 days Capsule, 10 mg 1/day Tooth pain Yes (dexamphetamine) Used tramadol before for 2 years for back pain, which had similar positive effects on NS. 10
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