256 Chapter 9 Table 2: Continued. Variable (>50% data available) Cluster 5 Cluster 6 Effect size Corrected p-value n5 Median (IQR) / Percentage n6 Median (IQR) / Percentage EIDS length per day 105 60 minutes: 18.1% 15-60 minutes: 32.4% 1-15 minutes: 39.0% <1 minute: 10.5% 91 60 minutes: 3.3% 15-60 minutes: 28.6% 1-15 minutes: 58.2% <1 minute: 9.9% -0.190 0.0373 Variable (<50% data available) Cluster 5 Cluster 6 Effect size Corrected p-value n5 Median (IQR) / Percentage n6 Median (IQR) / Percentage HLA-DQB1*0602 positivity† 66 33.0% 80 65.0% 0.315 0.0034 Presence – Memory complaints† 41 68.3% 30 26.7% 0.411 0.0086 Length of scheduled naps 81 52.2 (20.9-114.8) 55 20.9 (10.4-52.2) -0.247 0.0273 CSF Hypocretin-1 level 43 259.0 (173.0-366.0) 41 179.0 (73.0-299.5) -0.308 0.0281 Presence – Fatigue† 35 71.4% 27 37.0% 0.344 0.0346 Variables that were significantly different between clusters 5 and 6 are listed and split based on their availability (above and below 50%). Appendix B provides details on individual variables. The variables are included with the individual values for both clusters, and the effect size and corrected p value of the difference. Mann-Whitney U tests were performed (with effect size r), except when indicated otherwise. † Chi-square tests (and φ effect sizes) were used. AHI = apnoea-hypopnea index; EIDS = episodes of irresistible daytime sleep; HLA = human leukocyte antigen; IQR = interquartile range; PLMI = periodic leg movement index; PSG = polysomnography.
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