22 Chapter 1 narcolepsy type 1 with DWI analyses on white matter morphology (Chapter 5) and human postmortem immunohistochemistry analyses on axonal density, orientation and myelin integrity (Chapter 6). This is followed by fMRI studies to investigate the behavioural and neural correlates of sustained attention (Chapter 7) and active sleep resistance (Chapter 8) in narcolepsy type 1. The final two chapters on the future of central disorders of hypersomnolence in Section C compose unsupervised machine learning analyses to identify more reliable subgrouping of people with a central disorder of hypersomnolence to potentially improve diagnostic classification (Chapter 9) and a combined literature review, questionnaire and semi-structured interview study to investigate the potential of opioids as a treatment option for narcolepsy type 1 (Chapter 10). The culmination of the thesis will be presented in Chapter 11, a comprehensive discussion wherein the findings will be summarized and contextualized in scientific discourse with proposed avenues for future research.
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