218 Chapter 7 higher difficulty level blocks, people with narcolepsy type 1 were less able than controls to activate task-positive networks over time. This possibly reflects their difficulties in transitioning from attention initiation to stable attention levels, specifically when vigilance demand is high. Lower motor-related activity was also seen in people with narcolepsy in relation to making errors, associated with impaired response inhibition. Better knowledge of vigilance-related networks will contribute to a better understanding of narcolepsy and other disorders of sleep and wakefulness, and possibly underlie more tailored approaches to therapeutic, medicated or non-medicated, improvement of vigilance complaints in narcolepsy. Acknowledgements The authors would like to thank Sophie Schwartz, Aad Pors, Bo Scheffer for their help in scanning protocol composition and data acquisition and Riccardo Galli, Ingeborg de Koe and Neelam Habiboellah for their help in data analysis. Authorship contribution statement Conception and design of the study: JKG, YDW, GJL, RF. Acquisition of data: YDW, GJL, RF. Analysis of data: JKG, YDW, GJL, RF. Interpretation of results: JKG, YDW, GJL, RF. Manuscript writing and revisions: JKG, YDW, GJL, RF. Disclosure statement Financial disclosure: This project has been sponsored by Leiden University Fund / Den Dulk-Moermans Fund. The funding source was not involved in study design; the collection, analysis and interpretation of data; in the writing of the report or in the decision to submit the article for publication. Non-financial disclosure: none.
RkJQdWJsaXNoZXIy MjY0ODMw