Thesis

203 Attention Regulation in Narcolepsy Type 1 minimum significant clusters size of 20 voxels were used. If time-series plots generated by FSL showed possible outliers, the corresponding analysis was repeated with automatic outlier deweighting. The exact location of significant clusters was determined using the AAL and Brodmann+ atlases in the WFU PickAtlas toolbox (Wake Forest University, Winston-Salem, NC, USA, version 3) as part of SPM 12. Results Demographic and clinical data Data of 12 people with narcolepsy type 1 and 11 healthy controls were included as MRI scan acquisition failed in one healthy control. Both groups were comparable in age, IQ, and sex distribution (Table 1). Typical narcolepsyrelated clinical measures were seen in those with narcolepsy type 1, including a significantly higher ESS score than controls (10.08 ± 3.00 vs. 2.64 ± 1.96; t(21) = −6.97, p < 0.001). All participants with narcolepsy type 1 were HLA DQB1*06-02 positive. Table 1: Characteristics of the study population Patients (n = 12) Healthy controls (n = 11) P-value Male:female (N:N) 8:4 7:4 0.879 Age (years, mean, SD) 33.25 (10.50) 31.82 (13.39) 0.777 IQ score (mean, SD) 110.58 (10.73) 111.30 (8.25) 0.865 Age of onset EDS (years, mean, SD) 19.42 (9.15) - EDS duration (years, median, IQR) 10.00 (6.00-25.25) - Cataplexy presence 9/12 - Cataplexy and/or hypocretin deficiency (N, %) 12/12 - HLA DQB1*0602 presence (N, %) 12/12 - ESS score (mean, SD) 10.08 (3.00) 2.64 (1.96) < 0.001 MSLT: - Sleep latency (minutes, mean, SD) 4.62 (3.64) - - SOREM periods (mean, SD) 2.58 (1.57) - EDS = excessive daytime sleepiness; HLA = human leukocyte antigen; ESS = Epworth sleepiness scale; IQ = intelligence quotient; IQR = interquartile range; MSLT = multiple sleep latency test; SD = standard deviation; SOREM = sleep-onset rapid eye movement. 7

RkJQdWJsaXNoZXIy MjY0ODMw