190 Chapter 6 Supplementary Table 4: Colour intensity and axonal injury area percentage stained excluding opiates case Staining β Standard error 95% CI t-value p-value Effect size Axonal density (Bielschowsky silver staining colour intensity) -0.02 0.03 -0.08, 0.03 -0.821 0.431 0.23 Axonal injury (SMI312 area percentage stained) 0.48 0.68 -1.03, 1.94 0.71 0.498 0.17 Myelin integrity (PLP colour intensity) -0.001 0.02 -0.04, 0.04 -0.06 0.953 0.01 Myelin integrity (LFB colour intensity) 0.02 0.04 -0.05, 0.10 0.68 0.511 0.21 PLP = proteolipid protein; LFB = luxol fast blue. Supplementary Table 5: Post-hoc colour intensity and area percentage stained analyses excluding opiates case Staining Region Narcolepsy type 1 Mean (SD) Controls Mean (SD) p-value q-value Effect size Axonal density (Bielschowsky silver staining colour intensity) Reticular formation (RF) 0.60 (0.05) 0.68 (0.08) 0.155 0.349 1.03 Pyramidal tract (P) 0.68 (0.03) 0.73 (0.03) 0.047 0.212 1.58 Proximal corpus callosum (P-CC) 0.83 (0.05) 0.84 (0.08) 0.727 0.788 0.23 Distal corpus callosum (D-CC) 0.76 (0.08) 0.78 (0.10) 0.724 0.788 0.23 Anterior cingulate gyrus (ACC) 0.77 (0.02) 0.74 (0.09) 0.565 0.788 0.39 Cingulate sulcus (CS) 0.81 (0.07) 0.71 (0.09) 0.143 0.349 1.07 Primary visual cortex (V1) 0.77 (0.08) 0.80 (0.07) 0.481 0.788 0.48 Secondary visual cortex (V2) 0.83 (0.06) 0.84 (0.06) 0.788 0.788 0.18 Vermis (CB) 0.76 (0.06) 0.86 (0.05) 0.041 0.212 1.64
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