187 Axonal Loss in Narcolepsy Type 1 Supplementary Table 2: Post-hoc colour intensity and area percentage stained analyses Staining Region Narcolepsy type 1 Mean (SD) Controls Mean (SD) p-value q-value Effect size Axonal density (Bielschowsky silver staining colour intensity) Reticular formation (RF) † 0.60 (0.04) 0.68 (0.08) 0.089 0.401 1.12 Pyramidal tract (P) 0.71 (0.07) 0.73 (0.03) 0.570 0.960 0.36 Proximal corpus callosum (P-CC) 0.82 (0.04) 0.84 (0.08) 0.650 0.960 0.28 Distal corpus callosum (D-CC) 0.78 (0.08) 0.78 (0.10) 0.960 0.960 0.03 Anterior cingulate gyrus (ACC) 0.73 (0.08) 0.74 (0.09) 0.897 0.960 0.08 Cingulate sulcus (CS) 0.76 (0.11) 0.71 (0.09) 0.456 0.960 0.47 Primary visual cortex (V1) 0.80 (0.09) 0.80 (0.06) 0.904 0.960 0.08 Secondary visual cortex (V2) 0.83 (0.05) 0.84 (0.06) 0.781 0.960 0.17 Vermis (CB) † 0.74 (0.07) 0.86 (0.05) 0.030 0.270 1.89 Axonal injury (SMI312 area percentage stained) Reticular formation (RF) 24.43 (2.56) 23.23 (1.97) 0.450 0.908 0.48 Pyramidal tract (P) 26.31 (2.01) 24.47 (0.98) 0.114 0.734 1.08 Proximal corpus callosum (P-CC) # 21.70 (3.01) 23.00 (4.20) 0.730 0.908 0.31 Distal corpus callosum (D-CC) 22.82 (2.45) 22.33 (2.77) 0.793 0.908 0.16 Anterior cingulate gyrus (ACC) 19.33 (4.60) 20.29 (1.94) 0.681 0.908 0.26 Cingulate sulcus (CS) 21.12 (2.46) 20.56 (4.09) 0.818 0.908 0.14 Primary visual cortex (V1) 21.31 (1.60) 20.54 (2.67) 0.629 0.908 0.30 Secondary visual cortex (V2) 21.02 (1.74) 21.20 (2.62) 0.908 0.908 0.07 Vermis (CB) 26.23 (1.32) 23.73 (2.96) 0.163 0.734 0.93 6
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