181 Axonal Loss in Narcolepsy Type 1 chronic sleep-wake alterations. This underscores the need and provides essential novel targets for future in-vivo structural and functional narcolepsy type 1 neuroimaging studies, particularly into possible mediating roles for the ascending reticular activating system, pyramidal tract, corpus callosum and anterior cingulate gyrus in narcolepsy type 1 symptomatology. Acknowledgements The authors would like to thank all brain donors and their next of kin for brain donation. We would also like to thank the Netherlands Brain Bank (NBB) autopsy teams and Irene Frigerio for providing the SMI312 pixel classifier script. Lastly, we acknowledge Nathan Machluf and Rick Zwerver for their assistance in the analyses. This research received no specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Authorship contribution statement Conception and design of the study: JKG, LS, YDW, GJL, LEJ, RF, GJS. Acquisition of data: JKG, LS, GJS. Analysis of data: JKG, ACEB, LS, JGJMB, AWH, LEJ, GJS. Interpretation of results: JKG, ACEB, AWH, YDW, GJL, LEJ, RF, GJS. Manuscript writing and revisions: JKG, ACEB, LS, JGJMB, SWH, YDW, GJL, LEJ, RF, GJS. Disclosure statement Financial disclosure: nothing relevant to disclose. Non-financial disclosure: nothing relevant to disclose. 6
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