174 Chapter 6 Table 3: Axonal density analyses Region Outcome measure β Standard error 95% CI t-value p-value q-value Effect size Reticular formation Axon count -244.16 57.54 -360.01, -128.30 -4.24 0.0001 0.0008 1.36 Pyramidal tract Axon count -182.51 62.89 -309.14, -55.88 -2.90 0.006 0.016 0.93 Proximal corpus callosum Axon count -18.53 5.45 -29.49, -7.56 -3.40 0.002 0.008 1.08 Anterior cingulate gyrus Axon count -10.33 4.34 -19.08, -1.59 -2.38 0.023 0.046 0.77 Vermis Axon count 1.31 2.03 -2.78, 5.40 0.65 0.522 0.597 0.21 Proximal corpus callosum Axonal orientation ratio -0.81 0.88 -2.58, 0.95 -0.93 0.360 0.480 0.30 Anterior cingulate gyrus Axonal orientation ratio 0.68 0.71 -0.75, 2.12 0.96 0.342 0.480 0.31 Vermis Axonal orientation ratio -0.001 0.06 -0.13, 0.12 -0.01 0.989 0.989 0.00 The absolute axon count represents the axon count in the main fibre direction. The axon orientation ratio is calculated as the ratio of the axon counts in and perpendicular to the main fibre direction. q-values correspond to significance levels after the Benjamini–Hochberg procedure to decrease the false discovery rate to 0.05. q-values below 0.05 are made bold. NT1 = Narcolepsy type 1; SD = standard deviation.
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