170 Chapter 6 Table 2: Clinical-Pathological Information Donor ID Sex Age (year) PMD (year) Disease duration (year) CSF-pH Brain weight (gram) HCRT cells (count) Braak NFT stage Amyloid stage Braak LB stage Cause of death Relevant medication NT1 donor 1 Female 66 7.0 52 6.6 1,175 1,638 1 A 0 Heart failure Amphetamine, modafinil, sodium oxybate NT1 donor 2 Female 71 6.6 41 6.3 1,215 9,451 4 A 0 Heart failure, renal insufficiency Modafinil, sodium oxybate NT1 donor 3 Female 82 5.5 65 6.5 1,165 1,435 2 O 0 Pneumonia Modafinil NT1 donor 4 (chronic opiate use) Female 85 3.7 70 6.8 1,206 16,384 1 O 0 Chronic pain syndrome with palliative sedation Morphine (for 9 years), modafinil, midazolam (last 24 hours) Control 1 Female 64 5.7 N/A 6.4 1,221 48,946 0 O 0 Legal euthanasia Oxycodone, morphine, fentanyl, prednisolone, promethazine, codeine, oxazepam Control 2 Female 74 7.4 N/A 7.0 1,167 50,188 2 O 0 End-stage pancreas carcinoma, cachexia Promethazine Control 3 Female 83 7.8 N/A 6.5 1,072 53,183 2 O 0 Heart failure, cachexia -
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