152 Chapter 5 axonal density, lower myelination and/or greater axon diameter [213, 231]. Given the extent of the WM abnormalities, our results indicate a more complex cascade or a secondary pathway causing these differences, not solely explained by hypocretin deficiency on its own. Acknowledgements The authors would like to thank Sophie Schwartz, Aad Pors and Bo Scheffer for their help in scanning protocol composition and data acquisition. No conflicts of interest were present. Authorship contribution statement Conception and design of the study: JKG, RF, AL, DAK, GJL, YDW. Acquisition of data: RF, GJL, YDW. Analysis of data: JKG, RF, AL, DAK, GJL, YDW. Interpretation of results: JKG, RF, AL, DAK, GJL, YDW. Manuscript writing and revisions: JKG, RF, AL, DAK, GJL, YDW. Disclosure statement Financial disclosure: This project has been sponsored by Leiden University Fund / Den Dulk-Moermans Fund. The funding source was not involved in study design; the collection, analysis and interpretation of data; in the writing of the report or in the decision to submit the article for publication. Non-financial disclosure: none.
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