145 White Matter Connectivity in Narcolepsy Type 1 Figure 3. The significant ROIs displayed in native space of one subject, for visualization purposes. The mean (and 95% confidence interval) FA and MD values are plotted for patients (P) and controls (C) separately with the corresponding p-value on top. The unrounded p-value for the midbrain was p = .049693 (**). After Bonferroni correction for multiple comparisons only the left ventral diencephalon (*) maintained significant. Tractography (III) Statistically significant lower FA [F(1,19) = 9.287, p = .007] and lower tract volume [F(1,18) = 5.256, p = .034] were found in the WM tracts connecting the left hypothalamus with the midbrain (Table 4, Figure 4). Only the lower FA maintained its significance after Bonferroni correction for multiple comparisons (p < .0083). No statistically significant differences were seen in MD. All fibres running through the hypothalamus are bilaterally visualized in Appendix A, Supplementary Video 1 for the same subject that is presented in Figure 4. 5
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