Thesis

143 White Matter Connectivity in Narcolepsy Type 1 Table 2: Region-of-interest FA and MD analyses Fractional anisotropy Mean diffusivity Patients (mean, SD) Controls (mean, SD) P-value Patients (mean, SD) Controls (mean, SD) P-value Left thalamus 0.370 (0.015) 0.387 (0.020) 0.032 0.755 (0.020) 0.745 (0.019) 0.229 Right thalamus 0.348 (0.013) 0.360 (0.015) 0.061 0.785 (0.018) 0.788 (0.029) 0.746 Left amygdala 0.245 (0.017) 0.244 (0.027) 0.942 0.811 (0.017) 0.807 (0.027) 0.614 Right amygdala 0.240 (0.017) 0.238 (0.013) 0.897 0.838 (0.021) 0.848 (0.040) 0.499 Left ventral diencephalon 0.489 (0.016) 0.521 (0.021) 0.001 0.846 (0.061) 0.799 (0.042) 0.030 Right ventral diencephalon 0.482 (0.017) 0.506 (0.028) 0.019 0.866 (0.043) 0.834 (0.056) 0.129 Left hypothalamus 0.293 (0.026) 0.299 (0.026) 0.483 1.144 (0.127) 1.328 (0.399) 0.165 Right hypothalamus 0.280 (0.021) 0.292 (0.026) 0.186 1.210 (0.128) 1.209 (0.209) 0.968 Left lateral orbitofrontal WM 0.393 (0.020) 0.401 (0.020) 0.301 0.751 (0.025) 0.741 (0.017) 0.287 Right lateral orbitofrontal WM 0.397 (0.021) 0.401 (0.018) 0.588 0.740 (0.029) 0.731 (0.022) 0.430 Left medial orbitofrontal WM 0.368 (0.024) 0.376 (0.030) 0.359 0.750 (0.032) 0.743 (0.020) 0.612 Right medial orbitofrontal WM 0.385 (0.028) 0.397 (0.033) 0.368 0.767 (0.020) 0.770 (0.026) 0.738 Left anterior cingulate WM 0.535 (0.025) 0.534 (0.023) 0.921 0.768 (0.039) 0.769 (0.034) 1.000 Right anterior cingulate WM 0.557 (0.024) 0.566 (0.038) 0.365 0.803 (0.031) 0.814 (0.032) 0.457 Left parahippocampal WM 0.413 (0.008) 0.420 (0.032) 0.391 0.786 (0.014) 0.779 (0.034) 0.550 Right parahippocampal WM 0.419 (0.018) 0.422 (0.028) 0.604 0.803 (0.027) 0.803 (0.035) 1.000 Midbrain 0.530 (0.058) 0.575 (0.018) 0.050* 1.038 (0.121) 1.119 (0.077) 0.086 * Unrounded p-value = 0.049693. FA = fractional anisotropy; MD = mean diffusivity; SD = standard deviation; WM = white matter. 5

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