117 Potential Immunological Triggers for Central Disorders of Hypersomnolence of whom 18 individuals (78.3%) developed narcolepsy type 1 symptoms within one month of the infection. These reported infections included flu (N = 7), EBV (N = 3), fever of unknown origin (N = 2), pharyngitis (N = 1), pneumonia (N = 1), tonsillitis (N = 1), rhinitis (N = 1), otitis (N = 1) and enterovirus (N = 1). The exact timings were known in 23 individuals in the influenza vaccination group, of whom two people (8.7%) developed narcolepsy type 1 symptoms within one month after their H1N1 influenza vaccination. Disease progression Narcolepsy type 1 progression was also reported concerning immunological events. Six people already had EDS reported cataplexy development after an immunological event (two people after flu infection, two after pharyngitis, one after an EBV infection and one after H1N1 influenza vaccination). EDS development in people with cataplexy was reported in two people after an immunological event (one person after an EBV infection and one after H1N1 influenza vaccination). Other life events Multiple other life events before narcolepsy symptom onset (that were not part of the semi-structured clinical interview) were also sporadically reported in the medical records. They included traumatic brain injury (N = 3), childbirth (N = 1), increased anti-GAD34 levels (N = 1), human papillomavirus (HPV) vaccination (N = 3), combined diphtheria, pertussis, tetanus, polio and hepatitis A vaccination (N = 1), hepatitis B vaccination (N = 1), combined hepatitis A and B vaccination (N = 1) and unspecified holiday vaccinations (N = 1). 4
RkJQdWJsaXNoZXIy MjY0ODMw