114 Chapter 4 Appendix A Definitions of included groups and outcome measures Clinical diagnosis of narcolepsy type 1: people with a hypocretin-1 level between 110 and 150, or people with typical cataplexy and an MSLT sleep latency between eight and 12 minutes or just one SOREMP. Clinical diagnosis of narcolepsy type 2: people without cataplexy, at least two SOREMPs and a sleep latency between eight and 12 minutes. Clinical diagnosis of idiopathic hypersomnia: people without cataplexy, fewer than two SOREMPs and a sleep latency between eight and 12 minutes. Missing infection and/or influenza vaccination history: no mention of an infection and/or influenza vaccination in the medical records before hypersomnolence onset. No infection and/or influenza vaccination: explicit mention in the medical records that there was no infection and/or influenza vaccination before hypersomnolence disorder onset. Disease progression of narcolepsy type 1: physician-verified substantial increase in EDS or cataplexy, or the new development of either EDS or cataplexy when the other symptom was already present. Disease progression of narcolepsy type 2 or idiopathic hypersomnia: physicianverified substantial increase in EDS.
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