99 Potential Immunological Triggers for Central Disorders of Hypersomnolence Immunological events before narcolepsy type 1 onset Infection and/or influenza vaccination history was known in 194 people with narcolepsy type 1, of whom the infection history was known in 149 (Figure 1A) and the influenza vaccination history in 142 (Figure 1B). An infection and/or influenza vaccination were reported before developing narcolepsy type 1 in 87/194 individuals (44.8%). Thirteen individuals reported both an infection and influenza vaccination before the onset of their symptoms. These individuals were included in Figure 1 in the group of the immunological event closer to their start of narcolepsy type 1 symptoms (for five people, this was an infection and five influenza vaccination). In the remaining three, the infection and influenza vaccination were similarly close to narcolepsy type 1 onset and they were included in both the infection and influenza vaccination groups. Figure 1. Immunological events overview for narcolepsy type 1. If no exact timing of the immunological event was known, this individual was not included in column 3. EBV = Epstein–Barr virus; NT1 = narcolepsy type 1. Infection history An infection before onset of narcolepsy type 1 symptoms was reported in 46/149 (30.9%; Figure 1A). Flu was reported most (13/149, 8.7% of total sample), followed 4
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