98 Chapter 4 Table 1: Population characteristics Variable Narcolepsy type 1 (N = 194) Narcolepsy type 2 (N = 18) Idiopathic hypersomnia (N = 53) p-value N Median (IQR) / Percentage N Median (IQR) / Percentage N Median (IQR) / Percentage Gender (female) 194 51.0% 18 72.2% 53 58.5% 0.1717 Age at onset EDS (years) 183 13.1 (10.0–18.0) 17 16.7 (15.7–24.0) 45 17.0 (14.5–20.9) <0.0001 Cataplexy presence 194 94.8% 18 0.0% 53 0.0% <0.0001 Age at onset cataplexy (years) 149 15.0 (11.2–23.0) - - - - - MSLT sleep latency (minutes) 159 4.0 (2.4–6.0) 17 5.0 (2.8–7.2) 52 6.9 (5.7–9.1) <0.0001 Total number of SOREMPs 170 4.0 (2.0–5.0) 17 3.0 (2.0–5.0) 52 0.0 (0.0–0.0) <0.0001 MSLT SOREMP number 170 3.0 (2.0–4.0) 17 3.0 (2.0–4.5) 52 0.0 (0.0–0.0) <0.0001 PSG SOREMP presence 185 57.8% 18 50.0% 52 1.9% <0.0001 MSLT REM latency (minutes) 123 3.9 (2.3–6.0) 16 5.2 (2.4–7.2) 1 13.5 0.2717# CSF hypocretin-1 levels (pg/mL) 82 <40: 65.9% 40-110: 24.4% >110: 9.8% 6 <40: 0% 40-110: 0% >110: 100% 5 <40: 0% 40-110: 0% >110: 100% <0.0001 HLA-DQB1*0602 positivity 156 98.1% 15 80.0% 38 21.1% <0.0001 ESS score 111 16.0 (12.0–18.0) 14 16.0 (12.8–16.3) 44 15.0 (12.0–18.8) 0.9271 N reflects the available data for the corresponding variable. # The idiopathic hypersomnia group was not incorporated in this analysis and a Mann-Whitney U test was performed. EDS = excessive daytime sleepiness; MSLT = multiple sleep latency test; PSG = polysomnography; SOREMP = sleep-onset rapid eye movement period.
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