Thesis

72 Chapter 3 controlled trial and include longer term follow-up. Furthermore, maybe even more important, future studies should search for mediators and moderators to improve outcome in current efficacious treatments for BED. Declarations Ethics approval and consent to participate The design of the study was approved on October 10th 2011 by the medical ethics committee of the medical center of the Radboud University in Nijmegen, the Netherlands (CMO Radboud UMC: 2013/226). Prior to participation, all participants provided written informed consent after a clear explanation of the study procedures. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests other than TvS receiving royalties from the DEBQ and the EDI-3 and RDC being a paid statistical consultant for Health Outcomes Solutions, Winter Park, Florida. Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. Authors’ contributions TvS initiated the project and provided overall background supervision. ML collected the data and wrote the main part of the manuscript. MV supervised this process. RDC analyzed the data and wrote the statistical analysis and results sections. All authors were involved in interpretation of the data and contributed to writing the manuscript. All authors read and approved the final manuscript. Acknowledgements The authors wish to thank all therapists and support staff at Amarum who contributed to collecting the data, Liesbeth Verschoor for her assistance in entering the data, Wies van den Bosch and Thom van den Heuvel for supervising the DBT-arm and Machteld Ouwens for providing feedback on early versions of this paper.

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