TABLE OF CONTENTS 40 8 62 86 108 124 144 164 192 202 214 CHAPTER 1 General introduction and thesis outline CHAPTER 2 Evaluation of six methylation markers derived from genome-wide screens for detection of cervical precancer and cancer CHAPTER 3 Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV-positive women: results from a Dutch primary HPV-based screening cohort CHAPTER 4 Evaluation of DNA methylation biomarkers ASCL1 and LHX8 on hrHPVpositive self-collected samples from primary HPV-based screening CHAPTER 5 Direct bisulphite conversion of cervical samples for DNA methylation analysis CHAPTER 6 Colposcopy referrals and CIN3+ risk after triage of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation, ASCL1/LHX8 methylation and/or HPV genotyping CHAPTER 7 Low methylation marker levels among HPV-vaccinated women with cervical high-grade squamous intraepithelial lesions CHAPTER 8 General discussion and future perspectives CHAPTER 9 English summary CHAPTER 10 Nederlandse samenvatting | Dutch summary CHAPTER 11 Appendices
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