Thesis

60 Chapter 2 detecting endometrial and ovarian cancer using DNA methylation biomarkers in cervical scrapings. J Gynecol Oncol 2018; 29:e17. 49. Bierkens M, Hesselink AT, Meijer CJ, Heideman DA, Wisman GB, van der Zee AG, et al. CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease. Int J Cancer 2013; 133:1293-9. 50. Louvanto K, Aro K, Nedjai B, Butzow R, Jakobsson M, Kalliala I, et al. Methylation in Predicting Progression of Untreated Highgrade Cervical Intraepithelial Neoplasia. Clin Infect Dis 2020; 70:2582-90. 51. Kyrgiou M, Athanasiou A, Kalliala IEJ, Paraskevaidi M, Mitra A, Martin-Hirsch PP, et al. Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease. Cochrane Database Syst Rev 2017; 11:Cd012847. 52. Kremer WW, Berkhof J, Bleeker MC, Heideman DA, van Trommel NE, van Baal MW, et al. Role of FAM19A4/miR1242 methylation analysis in predicting regression or non-regression of CIN2/3 lesions: a protocol of an observational longitudinal cohort study. BMJ Open 2019; 9:e029017. 53. Gok M, Heideman DA, van Kemenade FJ, de Vries AL, Berkhof J, Rozendaal L, et al. Offering self-sampling for human papillomavirus testing to non-attendees of the cervical screening programme: Characteristics of the responders. Eur J Cancer 2012; 48:1799-808. 54. Arbyn M, Smith SB, Temin S, Sultana F, Castle P. Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. BMJ 2018; 363:k4823. 55. Hesselink AT, Heideman DA, Steenbergen RD, Gok M, van Kemenade FJ, Wilting SM, et al. Methylation marker analysis of selfsampled cervico-vaginal lavage specimens to triage high-risk HPV-positive women for colposcopy. Int J Cancer 2014; 135:880-6. 56. Kremer WW, Van Zummeren M, Novianti PW, Richter KL, Verlaat W, Snijders PJ, et al. Detection of hypermethylated genes as markers for cervical screening in women living with HIV. J Int AIDS Soc 2018; 21:e25165.

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