56 Chapter 2 Methylation marker non-CV AUC Sensitivity* Specificity* LOOCV AUC Sensitivity* Specificity* ASCL1 0.888 86.9% 79.3% 0.883 77.1% 88.6% LHX8 0.849 76.6% 82.1% 0.842 76.6% 81.0% ST6GALNAC5 0.794 62.3% 88.4% 0.787 60.6% 89.8% GHSR 0.811 67.4% 83.8% 0.804 65.7% 85.5% SST 0.778 57.1% 89.8% 0.770 58.3% 88.1% ZIC1 0.846 72.0% 85.2% 0.840 66.3% 90.3% * Sensitivities and specificities are calculated for CIN3 detection and based on Youden’s J-index. Abbreviations: AUC, area under the curve; CIN, cervical intraepithelial neoplasia; LOOCV, leave-oneout cross validation; non-CV, non-cross-validated Supplementary Table 2.2 Area under the curve (AUC) received from logistic regression and LOOCV analysis for CIN3 detection of six DNA methylation markers (ASCL1, LHX8, ST6GALNAC5, GHSR, SST and ZIC1) with age of the patient included as a covariate into the models. SUPPLEMENTARY INFORMATION Methylation marker ASCL1 LHX8 ST6GALNAC5 GHSR SST ZIC1 ASCL1 - 0.80 0.76 0.74 0.69 0.75 LHX8 0.80 - 0.73 0.79 0.74 0.79 ST6GALNAC5 0.76 0.73 - 0.70 0.64 0.68 GHSR 0.74 0.79 0.70 - 0.81 0.83 SST 0.69 0.74 0.64 0.81 - 0.81 ZIC1 0.75 0.79 0.68 0.83 0.81 - Supplementary Table 2.1 Correlation between DNA methylation markers ASCL1, LHX8, ST6GALNAC5, GHSR, SST and ZIC1 expressed by Spearman correlation coefficients.
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