General discussion and future perspectives 183 8 economic evaluation, including cost-effectiveness analysis and decisions regarding reimbursement. Assessing the economic impact of implementing methylation-based IVD tests and making informed reimbursement decisions is essential for successful integration into screening practice. 8.3 CONCLUSION In summary, the studies presented in this thesis underscore the efficacy of methylation markers, including FAM19A4/miR124-2 and ASCL1/LHX8, for use in cervical cancer screening. As we continue to refine and validate methylation markers, we progress towards the establishment of a comprehensive and effective risk-based screening approach. Methylation analysis holds the promise of making a substantial impact on early cervical cancer detection and prevention, ultimately enhancing the health and wellbeing of women worldwide. The strategies proposed in this thesis provide a clear path for future research and the integration of methylation analysis into cervical cancer screening programs.
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