154 Chapter 7 DATA AND STATISTICAL ANALYSES Only cases with histologically confirmed LSIL or HSIL following the 25-year-old follow-up visit were included in the analyses. This allows us to evaluate the methylations tests’ ability to identify women with HSIL cervical lesions. The final study population consisted of 15 LSIL and 17 HSIL cases, along with 371 controls. Groups were compared for differences in baseline characteristics, HPV genotypes and DNA methylation results using KruskalWallis comparison. Fisher’s exact test was used if the number of observations was lower than five, with post hoc testing using Bonferroni-corrected test. Methylation levels of HPV-vaccinated women were compared with those of unvaccinated women, stratified by disease category. The methylation data of the unvaccinated group were obtained from previously published data 11, 12, 23. All statistical tests performed were two-sided HPV genotypes by follow-up visits CASE 18 years 22 years 25 years 1 HSIL neg neg 33, 59 2 HSIL neg 33 33, 59, 66 3 HSIL neg 39, 68 58 4 HSIL - 51, 56, 66 52, 59, 61, 70 5 HSIL 6, 52 52, 56, 58 52, 58 6 HSIL neg 52 52 7 HSIL neg 66 6, 51 8 HSIL - 59 39, 59 9 HSIL neg 51 51 10 HSIL - 33, 39, 51 6, 33, 52 11 HSIL neg neg 51 12 HSIL 66 neg 59 13 HSIL neg neg neg 14 HSIL neg 11, 35, 51 35 15 HSIL neg neg neg 16* HSIL neg 51, 52, 66 51, 56 17 HSIL neg 66 58, 87 * Persistent HPV infections are shown in bold. Abbreviations: HSIL, high-grade intraepithelial lesion: HPV, human papillomavirus; neg, negative Table 7.2 Individual HPV genotyping results* from the earlier screening rounds of the Finnish community and individually randomised trial cohorts of the 17 HPV vaccinated high-grade intraepithelial lesion (HSIL) biopsy confirmed cases.
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