93 Tau PET and cognition Table 4. Regional associations between [18F]flortaucipir BP ND and R1 and cognition. Memory (n=71) Executive functioning (n=64) Language (n=59) Attention (n=64) Model 1 Medial temporal BPND -0.43‡§ [-0.66 − -0.20] -0.08 [-0.34 – 0.16] -0.17 [-0.48 – 0.12] 0.00 [-0.28 – 0.28] R1 -0.04 [-0.30 – 0.22] 0.03 [-0.22 – 0.28] 0.10 [-0.18 – 0.38] 0.07 [-0.21 – 0.35] Lateral temporal BPND -0.22 [-0.48 – 0.04] -0.26* [-0.52 - -0.02] -0.37†§ [-0.66 − -0.11] -0.25 [-0.54 – 0.02] R1 0.03 [-0.22 – 0.27] 0.27* [0.04 – 0.50] 0.30* [0.04 – 0.57] 0.33†§ [0.08 – 0.57] Parietal BPND -0.23 [-0.52 – 0.07] -0.46†§ [-0.81 − -0.23] -0.34* [-0.76 − -0.03] -0.50†§ [-0.89 − -0.25] R1 0.06 [-0.18 – 0.30] 0.36†§ [0.15 – 0.60] 0.28* [0.02 – 0.57] 0.48†§ [0.26 – 0.71] Occipital BPND -0.27* [-0.54 − -0.00] -0.26* [-0.53 − -0.01] -0.40†§ [-0.73 − -0.14] -0.37†§ [-0.67 − -0.10] R1 0.13 [-0.12 – 0.37] 0.17 [-0.06 – 0.43] 0.28* [0.03 – 0.57] 0.31*§ [0.07 – 0.59] Frontal BPND -0.14 [-0.40 – 0.12] -0.34†§ [-0.65 − -0.13] -0.21 [-0.57 – 0.09] -0.33*§ [-0.67 − -0.08] R1 -0.12 [-0.37 – 0.13] 0.15 [-0.09 – 0.40] 0.13 [-0.15 – 0.41] 0.13 [-0.13 – 0.40] Model 2 Medial temporal BPND -0.44‡§ [-0.67 − -0.20] -0.08 [-0.34 − 0.17] -0.17 [-0.48 − 0.12] 0.01 [-0.28 − 0.29] R1 -0.09 [-0.33 − 0.15] 0.03 [-0.23 − 0.28] 0.10 [0.19 − 0.38] 0.07 [-0.21 − 0.35] Lateral temporal BPND -0.23 [-0.51 − 0.04] -0.19 [-0.46 − 0.05] -0.31* [-0.60 − -0.04] -0.16 [-0.45 − 0.11] R1 -0.05 [-0.30 − 0.21] 0.21 [-0.02 − 0.46] 0.22 [-0.04 − 0.49] 0.28* [0.03 − 0.54] Parietal BPND -0.23 [-0.55 − 0.09] -0.36†§ [-0.70 − -0.11] -0.27 [-0.68 − 0.05] -0.36* [-0.72 − -0.10] R1 -0.00 [-0.26 − 0.25] 0.27* [0.06 − 0.50] 0.22 [-0.05 − 0.52] 0.39†§ [0.17 − 0.62] Occipital BPND -0.26 [-0.57 − 0.04] -0.21 [-0.52 − 0.07] -0.33* [-0.68 − -0.03] -0.27 [-0.59 − 0.03] R1 0.02 [-0.25 − 0.28] 0.09 [-0.17 − 0.37] 0.15 [-0.13 − 0.46] 0.20 [-0.07 − 0.50] Frontal BPND -0.16 [-0.42 − 0.11] -0.33†§ [-0.64 − -0.11] -0.20 [-0.56 − 0.10] -0.31*§ [-0.66 − -0.06] R1 -0.14 [-0.39 − 0.11] 0.11 [-0.12 − 0.34] 0.11 [-0.16 − 0.39] 0.09 [-0.17 − 0.35] Models are adjusted for age, sex and education. [18F]Flortaucipir BP ND and R1 were included in the model separately (model 1) and simultaneously (model 2). Standardized β’s with 95% confidence intervals are reported. BPND = non-displaceable binding potential. *p<0.05, †p<0.01, ‡p<0.001, §p FDR<0.05. 4
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