Thesis

89 Tau PET and cognition Higher occipital BPND was independently associated with worse language (− 0.33 [−0.68 to − 0.03]) and higher frontal BPND with lower scores on executive functioning (− 0.33 [− 0.64 to − 0.11]) and attention (− 0.31 [− 0.66 to − 0.06]). Most significant associations survived FDR correction (Table 4). For [18F]flortaucipir R 1, lower values in the lateral temporal ROI were independently associated with worse attention (0.28 [0.03 to 0.54]), while low R1 values in the parietal ROI were with lower scores on executive functioning (0.27 [0.06 to 0.50]) and attention (0.39 [0.17 to 0.62]). After FDR correction, the association between lower R1 in the parietal ROI and worse attention remained (Table 4). 4

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