TABLE OF CONTENTS Chapter 1 Introduction 9 Part I: Methodological considerations 21 Chapter 2 Effect of Shortening the Scan Duration on Quantitative Accuracy of [18F]Flortaucipir Studies 23 Molecular Imaging and Biology (2021) Chapter 3 Longitudinal tau PET using 18F-flortaucipir: the Effect of relative Cerebral Blood Flow on (semi)quantitative parameters 49 The Journal of Nuclear Medicine (2023) Part IIa: Clinical applications – cognitive correlates 77 Chapter 4 Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer’s disease 79 European Journal of Nuclear Medicine and Molecular Imaging (2020) Chapter 5 Differential associations between neocortical tau pathology and blood flow with cognitive deficits in earlyonset vs late-onset Alzheimer’s disease 109 European Journal of Nuclear Medicine and Molecular Imaging (2022) Chapter 6 Changes in tau PET and relative cerebral blood flow as predictors of longitudinal cognitive trajectories on the Alzheimer’s continuum 141 Submitted Part IIb: Clinical applications – biomarkers 177 Chapter 7 Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi‑modal longitudinal imaging study 179 European Journal of Nuclear Medicine and Molecular Imaging (2023) Chapter 8 Longitudinal change in ATN biomarkers in cognitively normal individuals 205 Alzheimer’s Research & Therapy (2022) Chapter 9 Summary & Discussion 227 Appendices Nederlandse samenvatting 243 List of publications 257 List of author affiliations 261 List of theses of the Alzheimer Center Amsterdam 264 PhD portfolio 269 Dankwoord 270 About the author 275
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