Thesis

85 Tau PET and cognition Table 1. Overview of demographics, [18F]flortaucipir BP ND and R1. N=71 Diagnosis MCI due to AD (n) 10 AD dementia (n) 61 Age (years) 66 (8) Sex (female/male) 36/35 Education (Dutch Verhage scale) 6 [3-7] Fazekas score 1 [0-3] MMSE 23 (4) [18F]flortaucipir BP ND Medial temporal 0.25 ± 0.15 [-0.11 – 0.59] Lateral temporal 0.48 ± 0.30 [-0.12 – 1.29] Parietal 0.55 ± 0.43 [-0.16 – 1.83] Occipital 0.45 ± 0.40 [-0.05 – 1.82] Frontal 0.26 ± 0.27 [-0.22 – 0.94] [18F]flortaucipir R 1 Medial temporal 0.68 ± 0.06 [0.57 – 0.86] Lateral temporal 0.86 ± 0.08 [0.70 – 1.13] Parietal 0.87 ± 0.11 [0.61 – 1.30] Occipital 0.98 ± 0.10 [0.74 – 1.34] Frontal 0.88 ± 0.07 [0.74 – 1.11] Mean (SD) are reported for all variables, except for diagnosis (n), sex (nfemale/nmale) and education and Fazekas score (median [range]). For [18F]flortaucipir BP ND and R1 the range is additionally provided. Parametric [18F]flortaucipir images were not partial volume corrected. MCI = mild cognitive impairment, AD = Alzheimer’s disease, MMSE = Mini-Mental State Examination, BPND = nondisplaceable binding potential. Associations between [18F]flortaucipir BP ND and R1 Higher [18F]flortaucipir BP ND was associated with lower R1 within the lateral temporal (stβ − 0.32 [95%CI − 0.56 to − 0.08]), parietal (− 0.43 [− 0.72 to − 0.14]) and occipital (− 0.53 [− 0.78 to − 0.29]) ROI (Table 3). Higher BPND in the occipital ROI was also associated with lower R1 in the parietal ROI (− 0.38 [− 0.64 to − 0.12]). All associations remained significant after FDR correction (Table 3). Figure 1 shows a selection of scatterplots for these associations. Addition of Fazekas scores to the model did not notably change the results (Supplementary Table 1). Voxel-wise associations with cognition Voxel-wise analyses (model 1) revealed that, in general, higher [18F]flortaucipir BPND was associated with worse cognition (Figure 2). More specifically, higher 4

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