71 E ect of flow on longitudinal tau PET Supplementary Table 7. Required sample sizes (n) for [18F]flortaucipir for different effect sizes. The differences between two dependent means (matched pairs) was calculated, with an α (error probability) of 0.05 and a power (1-β error probability) of 0.80. To adhere to the typical duration of clinical trials in AD we calculated percentage change over an 18 month period and used those standard deviations as input for the sample size calculations. Calculations were performed using GPower v3.1.9.7. SCD = subjective cognitive decline. AD = Alzheimer’s disease. DVR = distribution volume ratio. SUVr = standardized uptake value ratio. SCD Expected change 0.5% 1% 2% 3% 4% 5% 6% 7% 8% 9% 10% DVR Braak I/II 14137117544333 3 Braak III/IV 117 31 10 6 5 4 4 3 3 3 3 Braak V/VI 13134116544333 3 SUVr80-100 Braak I/II 18047148654433 3 Braak III/IV 119 32 10 6 5 4 4 3 3 3 3 Braak V/VI 17746138554433 3 AD Expected change 0.5% 1% 2% 3% 4% 5% 6% 7% 8% 9% 10% DVR Braak I/II 22358169654443 3 Braak III/IV 324 83 23 12 8 6 5 4 4 4 4 Braak V/VI 497126331610 8 6 5 5 4 4 SUVr80-100 Braak I/II 3911002713 9 7 5 5 4 4 4 Braak III/IV 446 113 30 15 10 7 6 5 5 4 4 Braak V/VI 641162422013 9 7 6 5 5 4 3
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