Thesis

69 E ect of flow on longitudinal tau PET Supplementary Table 2. 18F-flortaucipir DVR, SUVr and R 1 values for amyloid negative (A-) SCD subjects. Mean ± SD are provided. SCD = subjective cognitive decline. AD = Alzheimer’s disease. DVR = distribution volume ratio ( = binding potential (BPND) + 1 ). SUVr = standardized uptake value ratio. DVR SUVr80-100 R1 SCD (n=26) BL FU %change BL FU %change BL FU %change Braak I/II 1.001 (0.083) 1.023z (0.091) 2.26 (2.16) 1.084a (0.116) 1.10ax (0.111) 1.57 (2.74) 0.712 (0.045) 0.721x (0.048) 1.24 (2.79) Braak III/IV 1.015 (0.035) 1.037z (0.032) 2.24 (1.73) 1.062 a (0.057) 1.082az (0.051) 1.92 (2.38) 0.841 (0.038) 0.849 x (0.044) 0.92 (2.28) Braak V/VI 1.020 (0.036) 1.0 36z (0.030) 1.61 (2.03) 1.046 a (0.047) 1.060ax (0.040) 1.39 (2.87) 0.936 (0.043) 0.939 (0.050) 0.35 (2.52) DVR vs. SUVr: a p<0.001 | BL vs. FU: x p<0.05, y p<0.01, z p<0.001 | %change DVR vs. %change SUVr: n.s. Supplementary Table 3. 18F-flortaucipir DVR, SUVr and R 1 values for amyloid positive (A+) SCD subjects. Mean ± SD are provided. SCD = subjective cognitive decline. AD = Alzheimer’s disease. DVR = distribution volume ratio ( = binding potential (BPND) + 1 ). SUVr = standardized uptake value ratio. A+ DVR SUVr80-100 R1 SCD (n=12) BL FU %change BL FU %change BL FU %change Braak I/II 1.122 (0.151) 1.158x (0.166) 3.22 (4.01) 1.243a (0.189) 1.272a (0.184) 2.45 (4.28) 0.700 (0.029) 0.698 (0.051) -0.36 (5.76) Braak III/IV 1.110 (0.095) 1.158y (0.137) 4.08 (3.52) 1.189 a (0.128) 1.235ay (0.154) 3.67 (2.87) 0.824 (0.030) 0.829 (0.041) 0.51 (3.66) Braak V/VI 1.090 (0.066) 1.134y (0.100) 3.90 (3.55) 1.140 a (0.091) 1.185ay (0.118) 3.85 (3.62) 0.904 (0.035) 0.911 (0.042) 0.75 (3.07) DVR vs. SUVr: a p<0.001 | BL vs. FU: x p<0.05, y p<0.01 | %change DVR vs. %change SUVr: n.s. 3

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