54 Chapter 3 Di erences in 18F-Flortaucipir DVR, SUVr, and R 1 SCD Subjects. DVR increased at follow-up in all regions (all P < 0.001), with the largest increase found in Braak III/IV (1.045–1.075, 2.82% ± 2.54%) (Table 2; Figure 1a; Supplementary Figure 2a). SUVr also significantly increased at follow-up in all regions (all P < 0.003). The largest increase was found in Braak III/IV (1.102–1.130, 2.47% ± 2.64%) (Table 2; Figures. 1c and 2c). Percentage change was significantly lower for SUVr than for DVR in Braak I/II (SUVr, 1.85% ± 3.27%, vs. DVR, 2.56% ± 2.85%; P=0.048). Braak III/IV and V/VI did not show any statistically significant differences between percentage change in DVR and SUVr (Table 2; Figure 2). Taking all regions together, the correlation coefficient between percentage change in SUVr and DVR was 0.83 (P< 0.001), and the bias as provided by Bland–Altman analysis was 0.41 ± 1.72 (Figures 3a and 3c). For R1, no significant decreases at follow-up were found in any region (Table 2). AD Patients. DVR increased at follow-up in all regions (all P < 0.001), with the largest increase found in Braak V/VI (1.284–1.379,7.25% ± 6.85%) (Table 2; Figure 1B; Supplementary Figure 2b). SUVr also increased at follow-up in all regions (all P < 0.009). Like DVR, the largest increase was found in Braak V/VI (1.382–1.495, 8.21% ± 8.03%) (Supplementary Table 3; Figure 1d; Supplementary Figure 2d). Percentage change was higher for SUVr than for DVR in Braak III/IV (SUVr, 7.52% ± 6.66%, vs. DVR, 6.61% ± 5.63%; P=0.047). No statistically significant differences between percentage change in SUVr and DVR were found for any other region (Table 2; Figure 2). Taking all regions together, the correlation coefficient between percentage change in SUVr and DVR was 0.94 (P < 0.001), and the bias as provided by Bland–Altman analysis was 20.55 ± 2.56 (Figures 3b and 3d). For R1, significant decreases at follow-up were found in Braak III/IV (0.835–0.821, 21.62% ± 3.71%, P=0.040) and V/VI (0.904–0.883, 22.28% ± 3.67%, P=0.003) (Table 2).
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