45 Shortening the scan duration SUPPLEMENTARY MATERIAL Supplementary Table 1. SRTM BPND obtained using the shortened time interval (0-60/80-100) compared to plasma-input DVR-1 and SRTM BPND obtained with the original scan duration. DVR-1 (0-60/80-130) SRTM BPND (0-60/80-130) HC AD HC AD r2 Slope r2 Slope r2 Slope r2 Slope SRTM BPND (0-60/80-100) 0.96 0.92 0.91 1.03 0.99 1.01 0.99 0.95 The correspondence for the original scan duration between SRTM BPND and DVR-1 was r2= 0.96 slope= 0.90 for HC and, r2= 0.93 slope= 1.09 for AD. Supplementary Table 2. RPM R1 obtained using shorter time intervals compared to SRTM R1 and RPM R1 obtained with the original scan duration. SRTM R1 (0-60/80-130) RPM R1 (0-60/80-130) HC AD HC AD r2 Slope r2 Slope r2 Slope r2 Slope RPM R1 (0-60/80-120) 0.97 1.00 0.97 0.99 1.00 1.00 1.00 1.00 RPM R1 (0-60/80-110) 0.97 1.00 0.97 0.99 1.00 1.00 1.00 1.00 RPM R1 (0-60/80-100) 0.97 1.00 0.97 0.99 1.00 1.00 1.00 1.00 The correspondence for the original scan duration between RPM R1 and SRTM R1was r2= 0.97 slope= 1.00 for HC and, r2= 0.97 slope= 0.99 for AD. Supplementary Table 3. Shortened time intervals interpolated using four different methods are compared with SRTM R1 obtained with the original scan duration. SRTM R1 (0-60/80-130) HC AD r2 Slope r2 Slope POP-IP 2T4k_VB SRTM R1 (0-50/80-100) 0.97 1.01 0.98 1.01 SRTM R1 (0-40/80-100) 0.96 1.00 0.97 1.01 SRTM R1 (0-30/80-100) 0.95 1.01 0.96 1.01 2
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