Thesis

219 Longitudinal change in ATN biomarkers Table 4. Associations between change in amyloid burden and cognitive test performance Baseline Longitudinal Positivenegative Negativepositive Positivepositive Positivenegative Negativepositive Positive-positive VAT-A 0.20 (0.30) 0.16 (0.21) 0.05 (0.16) 0.01 (0.11) 0.03 (0.05) 0.01 (0.04) RAVLT immediate 3.24 (3.36) 0.65 (2.40) -2.28 (1.88) -0.11 (0.88) 0.04 (0.36) -1.40 (0.32)* RAVLT delayed 0.88 (1.18) 0.55 (0.85) -0.96 (0.66) -0.03 (0.30) 0.05 (0.12) -0.51 (0.10)* Animal fluency 3.48 (2.13) 1.42 (1.51) 0.79 (1.18) 0.71 (0.57) -0.05 (0.23) -0.23 (0.21) TMT-A 0.01 (0.11) 0.13 (0.08) 0.05 (0.06) 0.03 (0.04) -0.04 (0.02) -0.01 (0.02) TMT-B 0.04 (0.13) 0.10 (0.10) -0.07 (0.08) 0.01 (0.03) -0.02 (0.01) -0.02 (0.01)* Stroop I 0.05 (0.07) 0.06 (0.05) 0.01 (0.04) 0.01 (0.02) -0.03 (0.01)* -0.01 (0.01) Stroop II 0.06 (0.07) 0.00 (0.05) 0.04 (0.04) 0.00 (0.02) -0.02 (0.01) -0.02 (0.01) Stroop III 0.12 (0.09) 0.01 (0.06) 0.02 (0.05) -0.01 (0.02) -0.03 (0.01)* -0.02 (0.01)* MMSE -0.23 (0.48) 0.06 (0.34) -0.29 (0.26) -0.14 (0.18) 0.01 (0.11) -0.06 (0.08) Data is presented as beta (SE) as estimated by linear mixed models. Models included a four level variable indicating change in amyloid status (negativenegative (reference), negative-positive, positive-negative and positive-positive), time and their interaction as predictors. All models were adjusted for age, sex and education. Outcome was cognitive test performance. Baseline estimates represent the association between the predictor and baseline test performance, longitudinal estimates represent the association of the interaction between predictor and time, and reflect the slope of cognitive test performance. VAT = visual association test, RAVLT = rey auditory verbal learning task, TMT = trail making test, MMSE = mini mental state examination. * p < 0.05. 8

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