216 Chapter 8 Associations between changes in amyloid status and cognitive test performance Finally, we investigated whether change in amyloid burden was associated with cognitive test performance over time, using our four-level variable (negative-negative (reference), positive-negative, negative-positive, positive-positive) as determinant. We did not find associations between change in amyloid status and baseline cognitive test performance (Table 4). By contrast, we found several associations with cognitive slope, as individuals in the negative-positive group had a steeper slope than negative-negative individuals on Stroop I and III. Positive-positive individuals showed a steeper decline on RAVLT immediate and delayed recall, TMT-B, and Stroop III. Positive-negative individuals did not differ from negative-negative individuals with regards to their cognitive test performance. Figure 3. Changes in amyloid status. Scatterplot showing baseline and follow-up BPND values. Different colors represent individuals with a negative amyloid PET scan at baseline and follow-up (negative-negative), a positive scan at baseline and a negative scan at follow-up (positive-negative), a negative scan at baseline and a positive scan at follow-up (negative-positive), and a positive scan at baseline and follow-up (positive-positive), respectively. The dashed lines represent a division in low, grey zone and high amyloid burden and is based on a previous study by our group (6), with thresholds of 0.19 and 0.29 BPND. BPND = binding potential.
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