215 Longitudinal change in ATN biomarkers baseline to high BPND at follow-up. When conversely focusing on the six individuals with grey zone BPND at baseline, three belonged to the negative-positive group, two to the positive-positive group, and one to the negative-negative group. This shows a considerable part of this group is on the verge of transitioning to a visually positive amyloid status. Subsequently, we investigated which factors predicted a change in amyloid status from negative to positive. Logistic regression analysis showed that APOE ε4 carriers had higher odds of transitioning to a positive amyloid status (OR 5.22 (95% CI 1.23–22.75), Table 2). Baseline age, sex, education, and baseline MMSE score were not associated with a higher odds of changing to amyloid positivity. When we analyzed amyloid accumulation rate as continuous outcome using linear mixed models (BPND; Table 3, Figure 4), we confirmed that APOE ε4 carriers had both higher baseline BPND values and a higher accumulation rate. Figure 2. Changes in ATN profiles. REM = rapid eye movement; MCI = mild cognitive impairment; AD = Alzheimer’s disease. 8
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