214 Chapter 8 Figure 1. Changes in biomarker status for A, T and N biomarker groups. Visualization of longitudinal changes in biomarker status for A, T, and N biomarker groups. Change in amyloid status over time To evaluate amyloid accumulation over time, Figure 3 visualizes changes in amyloid status in relation to actual BPND values at baseline and follow-up, using a division into low, grey zone, and high BPND. Overall, BPND in the composite ROI increased with 0.011 (SE 0.002) annually (p-value 0.00). Most individuals who were negative at baseline and at follow-up on visual rating (i.e., negative-negative) had low baseline and low follow-up BPND (54/58), and most positive-positive individuals had high baseline and high follow-up BPND (14/19). The amyloid status of 15 individuals changed over time (positive-negative n = 5, negative-positive n = 10). Most positive-negative individuals had both low baseline and low follow-up BPND (4/5). The group of negative-positive individuals was quite heterogeneous in terms of BPND values and had at baseline and follow-up low (4/10), grey zone (1/10), or high (1/10) BPND. Two changed from low baseline BPND to grey zone BPND at follow-up, and two changed from grey zone BPND at
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