212 Chapter 8 ATN biomarker information at follow-up and those who did not have complete ATN biomarker information at follow-up available. Table 1. Baseline demographics n Total (n=92) Baseline amyloid negative (n=68) Baseline amyloid positive (n=24) Age1 92 65.29±8.02 64.82±7.81 66.61±8.61 Sex, n female (%)2 92 39 (42%) 29 (43%) 10 (42%) Education, median [IQR]3 92 6 [5-6] 6 [5-6] 6 [5-7] APOE ε4 carriers, n (%)2 87 27 (31%) 14 (21%) 13 (62%)* [18F]florbetapir BP ND 3 92 0.16±0.12 0.11±0.05 0.30±0.16* [18F]flortaucipir BP ND 3 44 0.01±0.08 -0.01±0.05 0.05±0.11* MTA score3 92 0.25 [0-1] 0.50 [0-1] 0.00 [0-1] Fazekas3 91 0.96±0.82 0.96±0.84 0.96±0.75 Microbleeds, n (%)2 92 21 (23%) 15 (22%) 6 (25%) VAT-A3 92 11.61±0.94 11.62±0.98 11.58±0.83 RAVLT immediate1 92 44.64±7.68 44.76±7.07 44.29±9.37 RAVLT delayed1 92 9.00±3.26 9.34±3.02 8.03±3.75 Animal fluency3 92 24.30±6.22 24.09±6.16 24.92±6.49 TMT-A3 92 34.89±11.85 34.43±12.11 36.21±11.24 TMT-B3 92 81.03±40.55 80.93±44.89 81.33±25.21 Stroop I3 91 43.85±9.06 44.18±10.12 42.92±5.13 Stroop II3 90 59.48±11.64 60.13±12.49 57.57±8.68 Stroop III3 90 94.64±22.33 95.61±22.91 91.83±20.79 MMSE3 92 28.86±1.14 28.93±1.15 28.67±1.13 Baseline demographics for the total sample and for amyloid negative and positive individuals separately. Data is presented as mean±SD unless otherwise specified. Baseline amyloid status is determined by visual read of [18F]florbetapir PET. [18F]florbetapir BP ND is calculated in a composite ROI. [18F]flortaucipir BP ND is calculated in lateral temporal gyrus. MTA score is calculated by averaging right and left sides. Number of microbleeds is dichotomized into 0 counts and ≥ 1 counts, n shown is number of participants with ≥ 1 count. Neuropsychological test scores shown represent baseline values at the visit closest to the baseline [18F]florbetapir scan. BPND = binding potential; MTA = medial temporal atrophy; VAT = visual association test; RAVLT = rey auditory verbal learning task; TMT = trail making test; MMSE = mini mental state examination. 1 t-test; 2 chi-square test; 3 Mann-Whitney U test. * p < 0.05.
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