188 Chapter 7 Figure 2. Plots showing baseline tau PET BPND (a) and longitudinal tau PET BPND (b), cortical thickness (c) and (d) R1 in amyloid negative (green) and positive (red) individuals. Annual change tau PET BPND as determinant Linear mixed models did not yield any FDR-correction surviving associations between annual change in tau PET BPND and longitudinal cortical thickness in both Aβ+ and Aβ- individuals (Supplementary Figure 3). Longitudinal rCBF as outcome measure Baseline tau PET BPND as determinant Linear mixed models yielded no FDR-correction surviving associations between baseline tau PET BPND and longitudinal rCBF in neither Aβ+ nor Aβ- individuals (Supplementary Figure 2). Annual change tau PET BPND as determinant Linear mixed models showed that increases in tau PET BPND over time were associated with increases in R1 over time in the inferolateral and superior parietal gray matter in Aβ+ individuals (Supplementary Figure 4). No associations surviving correction for multiple comparisons were found in Aβ- individuals.
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