187 Longitudinal tau PET and atrophy whole group; Figure 2). We therefore did perform the LMMs with longitudinal rCBF as dependent variable. Longitudinal cortical thickness as outcome measure Baseline tau PET BPND as determinant In Aβ+ individuals, linear mixed models showed that higher tau BPND at baseline was associated with cortical thinning over time (Figure 3). More specifically, tau PET BPND in Braak III/IV was associated with a decrease in cortical thickness over time in widespread cortical regions, including parietal, (medial) frontal and (lateral) temporal lobes. Comparable results were observed with tau PET BPND in Braak V/VI as the determinant, although with generally lower effect sizes compared to Braak III/IV. Tau PET BPND in Braak I showed only weak associations (not surviving FDR-correction) with cortical thinning over time. In Aβ- individuals, no FDR-surviving associations were found for any of the Braak ROIs (Supplementary Figure 1). Figure 1. Overview of the study design. BL = baseline, rCBF = relative cerebral blood flow, Aβ = amyloid-β, SCD = subjective cognitive decline, AD = symptomatic Alzheimer’s disease 7
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