16 Chapter 1 biomarker associations, in chapter 7 we investigated the associations between changes in tau PET with imaging biomarkers of neuronal injury (i.e., atrophy and CBF) in a cohort comprising i) amyloid negative (Aβ-) cognitively normal (CN) individuals, and ii) amyloid positive (Aβ+) CN and cognitively impaired (CI) (AD-phenotype) individuals. Lastly, we identified determinants of change in AT(N) profiles over time in cognitively normal individuals by using tau PET in chapter 8. This thesis will be concluded by a summary and discussion of our findings and their implications.
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