174 Chapter 6 Supplementary Figure 12. Associations between annual change (AC) in R1 with cognitive test scores (over time) while adjusting for tau PET BPND using only cognitive data from the baseline PET scan onward. Model coefficients with 95% confidence intervals from linear mixed models with annual change in tau PET BPND (per ROI) and annual change in R1 as determinant, longitudinal cognitive test score (scaled) as outcome, adjusted for age-at-PET, sex, education, baseline tau PET BPND (per ROI) and baseline R1. Cross-sectional results represent the coefficient for “annual change in global cortical R1” and longitudinal results represent the coefficient for “annual change in global cortical R1 x time”. Red = PFDR<0.05. Blue = P<0.05. Grey = P≥0.05.
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