165 Longitudinal tau PET and cognition Supplementary Figure 3. Associations between baseline (BL) R1 with cognitive test scores (over time) while adjusting for tau PET BPND. Model coefficients with 95% confidence intervals from linear mixed models with baseline tau PET BPND (per ROI) and R1 as determinant, longitudinal cognitive test score (scaled) as outcome, adjusted for age-at-PET, sex and education. Cross-sectional results represent the coefficient for “baseline global cortical R1” and longitudinal results represent the coefficient for “baseline global cortical R1 x time”. The three lines represent models with Braak I, Braak III/IV, and Braak V/VI tau PET BPND. Red = PFDR<0.05. Blue = P<0.05. Grey = P≥0.05. 6
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